The history of Rignano, like that of other towns in the area, is linked to the Capenates, a flourishing pre-Roman population that controlled the territory between the Tiber Valley and Mount Soratte and had its major cult centre in the Sanctuary of the Goddess Feronia.
At the entrance to the town, a piece of road with typical Roman paving can still be seen: this is the route of the ancient Via Flaminia (3rd century B.C.) that ran parallel to the modern consular road.
After the Roman era, in the Middle Ages, the area maintained an agricultural vocation.
The first village probably formed around the Church of SS Abbondio and Abbondanzio, which became an important place of popular worship.
The town grew over the centuries, even changing its name several times, contended by the powerful noble families of central Italy. Numerous traces of these events can still be seen.